Fig. 1 · Structure
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Trimetazidine dihydrochloride
Antianginal Agent
Trimetazidine dihydrochloride is a selective inhibitor of long-chain 3-ketoyl coenzyme A thiolase, with an IC50 of 75 nM, thereby reducing beta-oxidation of free fatty acids. As an effective antianginal agent, it also exhibits cytoprotective, antioxidant, anti-inflammatory, antinociceptive, and gastroprotective properties. Additionally, Trimetazidine dihydrochloride induces autophagy and acts as a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor, making it useful for various research applications related to cardiovascular health and metabolic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 13171-25-0 |
| Applications | Antianginal Agent |
| Formula | C14H24Cl2N2O3 |
| Molecular Weight | 339.26 |
| SMILES | COC1=CC=C(CN2CCNCC2)C(OC)=C1OC.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.