Fig. 1 · Structure
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Trimethylcolchicinic acid
Trimethylcolchicinic acid is a colchicine analogue that primarily targets cellular sulfate production pathways. It enhances the synthesis of chondroitin sulfate in L cells while inhibiting dermatan sulfate production. Notably, this compound has demonstrated the ability to reduce liver fibrosis and cholestasis associated with prolonged biliary obstruction in rat models. Trimethylcolchicinic acid is valuable for research into liver fibrosis, gout, and cancer-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3482-37-9 |
| Formula | C19H21NO5 |
| Molecular Weight | 343.37 |
| Synonyms | Desacetylcolchiceine; N-Deacetylcolchiceine |
| SMILES | COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(O)C3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.