Fig. 1 · Structure
Documents & Downloads
Trk-IN-10
TRK Inhibitor
Trk-IN-10 is a selective inhibitor of tropomyosin receptor kinases (TRK) with IC50 values of 0.86 nM for TrkA and 6.92 nM for the TrkAG595R variant. As a receptor tyrosine kinase, TRK plays a crucial role in the development of solid tumors. Trk-IN-10 exhibits a noteworthy selectivity profile, showing an IC50 of 350 nM against ALK, which may help mitigate potential off-target effects and toxicity in therapeutic applications. This compound is valuable for research into TRK-related pathways and the treatment of neurotrophic receptor-driven malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2700265-61-6 |
| Applications | TRK Inhibitor |
| Formula | C20H20FN5O3 |
| Molecular Weight | 397.40 |
| SMILES | C[C@H]1CNC(C2=C3N=C4C(OC[C@H](N4CC5=CC=C(C=C5O1)F)C)=CN3N=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.