Trk-IN-10 is a selective inhibitor of tropomyosin receptor kinases (TRK) with IC50 values of 0.86 nM for TrkA and 6.92 nM for the TrkAG595R variant. As a receptor tyrosine kinase, TRK plays a crucial role in the development of solid tumors. Trk-IN-10 exhibits a noteworthy selectivity profile, showing an IC50 of 350 nM against ALK, which may help mitigate potential off-target effects and toxicity in therapeutic applications. This compound is valuable for research into TRK-related pathways and the treatment of neurotrophic receptor-driven malignancies.
Trk-IN-10 is a selective inhibitor of tropomyosin receptor kinases (TRK) with IC50 values of 0.86 nM for TrkA and 6.92 nM for the TrkAG595R variant. As a receptor tyrosine kinase, TRK plays a crucial role in the development of solid tumors. Trk-IN-10 exhibits a noteworthy selectivity profile, showing an IC50 of 350 nM against ALK, which may help mitigate potential off-target effects and toxicity in therapeutic applications. This compound is valuable for research into TRK-related pathways and the treatment of neurotrophic receptor-driven malignancies.
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