Fig. 1 · Structure
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Trk-IN-11
TRK Inhibitor
Trk-IN-11 is a highly effective inhibitor of tropomyosin receptor kinase (TRK), exhibiting IC50 values of 1.4 nM and 1.8 nM against TrkA and TrkAG595R, respectively. As a receptor tyrosine kinase, TRK plays a crucial role in the progression of solid tumors. This compound is valuable for studying TRK-related pathways and assessing therapeutic strategies in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2700265-62-7 |
| Applications | TRK Inhibitor |
| Formula | C21H22FN5O3 |
| Molecular Weight | 411.43 |
| SMILES | C[C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC(F)=CC=C5C2)C)=O)C=NN4C=C3OC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.