Fig. 1 · Structure
Documents & Downloads
TRK-IN-12
TRK Inhibitor
TRK-IN-12 is a selective TRK inhibitor, demonstrating potent activity with an IC50 of 13.1 nM against TRKG595R. This macrocyclic derivative exhibits significant antiproliferative effects in the Ba/F3-LMNA-NTRK1 cell line, achieving an IC50 value of 0.080 μM. Additionally, TRK-IN-12 outperforms the control agent in Ba/F3-LMNA-NTRK1-G595R with an IC50 of 0.646 μM, making it a valuable candidate for therapeutic research targeting TRK-mediated pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2823342-34-1 |
| Applications | TRK Inhibitor |
| Formula | C18H19ClFN5O3S |
| Molecular Weight | 439.89 |
| SMILES | CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.