Fig. 1 · Structure
Documents & Downloads
TRK-IN-17
TRK Inhibitor
TRK-IN-17 is a selective inhibitor of tropomyosin-related kinases (TRKs), a family of receptor tyrosine kinases activated by neurotrophins such as Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). This compound demonstrates significant anti-cancer properties by disrupting the signaling pathways that TRKs mediate, making it a valuable tool for investigating various malignancies. Research applications include the study of TRK-related cancer mechanisms and the development of targeted therapies for TRK-driven tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2409544-80-3 |
| Applications | TRK Inhibitor |
| Formula | C21H21F2N7S |
| Molecular Weight | 441.50 |
| SMILES | CCN/C(C1=CN=C2C=CC(N3C[C@H](C[C@@H]3C4=CC(F)=CC(SC)=C4)F)=NN12)=N\C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.