Fig. 1 · Structure
Documents & Downloads
Trk-IN-20
Trk Inhibitor
Trk-IN-20 is a potent inhibitor of Trk kinases, specifically targeting TrkA, TrkB, and TrkC with IC50 values of 1.6 nM, 2.9 nM, and 2.0 nM, respectively. By inhibiting the phosphorylation of these receptors, Trk-IN-20 effectively suppresses their kinase functions. This compound is valuable in research applications aimed at understanding neurotrophic signaling pathways and exploring therapeutic strategies for conditions related to Trk receptor dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2460924-63-2 |
| Applications | Trk Inhibitor |
| Formula | C22H18F2N4 |
| Molecular Weight | 376.40 |
| SMILES | FC1=CC([C@@H](C)NC2=CC3=C(C=C2)NN=C3/C=C/C4=NC=CC=C4)=CC(F)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.