TRK-IN-24 is a potent inhibitor of Trk receptors, specifically targeting TRKA, TRKC, TRKAG595R, TRKAG667C, and TRKAF589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, respectively. This compound demonstrates significant antitumor activity in xenograft models, including BaF3-CD74-NTRK1G595R and BaF3-CD74-NTRK1G667C. Additionally, TRK-IN-24 effectively inhibits the proliferation of Ba/F3 cells harboring various single mutants, achieving IC50 values ranging from 1.43 to 47.56 nM. This makes TRK-IN-24 a valuable tool for research applications focused on targeted cancer therapies.
TRK-IN-24 is a potent inhibitor of Trk receptors, specifically targeting TRKA, TRKC, TRKAG595R, TRKAG667C, and TRKAF589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, respectively. This compound demonstrates significant antitumor activity in xenograft models, including BaF3-CD74-NTRK1G595R and BaF3-CD74-NTRK1G667C. Additionally, TRK-IN-24 effectively inhibits the proliferation of Ba/F3 cells harboring various single mutants, achieving IC50 values ranging from 1.43 to 47.56 nM. This makes TRK-IN-24 a valuable tool for research applications focused on targeted cancer therapies.
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