TRK-IN-28 is a potent TRK inhibitor that demonstrates IC50 values of 0.55 nM, 25.1 nM, and 5.4 nM against TRKWT, TRKG595R, and TRKG667C, respectively. This compound exhibits antiproliferative activity, with IC50 values of 9.5 nM, 3.7 nM, 205.0 nM, and 48.3 nM in various Ba/F3 cell lines expressing ETV6-TRKAWT, ETV6-TRKBWT, LMNA-TRKG595R, and LMNA-TRKAG667C, respectively. TRK-IN-28 is valuable for research focused on TRK-related tumors and signaling pathways.
TRK-IN-28 is a potent TRK inhibitor that demonstrates IC50 values of 0.55 nM, 25.1 nM, and 5.4 nM against TRKWT, TRKG595R, and TRKG667C, respectively. This compound exhibits antiproliferative activity, with IC50 values of 9.5 nM, 3.7 nM, 205.0 nM, and 48.3 nM in various Ba/F3 cell lines expressing ETV6-TRKAWT, ETV6-TRKBWT, LMNA-TRKG595R, and LMNA-TRKAG667C, respectively. TRK-IN-28 is valuable for research focused on TRK-related tumors and signaling pathways.
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