TRK-IN-34 is a potent TRK and TRKC mutant kinase inhibitor, exhibiting IC50 values of 0.75 nM and 0.96 nM against TRKAG595R and TRKAG667C, respectively. This compound effectively inhibits the kinase activities of these mutations, leading to decreased proliferation of TRKA-transfected cells and demonstrating tumor growth-inhibitory effects in xenograft models. TRK-IN-34 is valuable for investigating cancers resistant to TRK inhibitors, particularly those driven by the TRKAG667C mutation.
TRK-IN-34 is a potent TRK and TRKC mutant kinase inhibitor, exhibiting IC50 values of 0.75 nM and 0.96 nM against TRKAG595R and TRKAG667C, respectively. This compound effectively inhibits the kinase activities of these mutations, leading to decreased proliferation of TRKA-transfected cells and demonstrating tumor growth-inhibitory effects in xenograft models. TRK-IN-34 is valuable for investigating cancers resistant to TRK inhibitors, particularly those driven by the TRKAG667C mutation.
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