Trk-IN-6

Catalog No.: A35025
Trk Receptor Inhibitor
Trk-IN-6 is a selective inhibitor of Trk receptors, demonstrating remarkable in vitro potency against various TRK mutants with IC50 values ranging from 0.2 to 0.7 nM. This compound is invaluable for studying the role of Trk signaling in cancer and neurodevelopmental disorders. Its high specificity makes it a reliable tool for elucidating the biological effects of Trk inhibition in research applications.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTrk-IN-6 is a selective inhibitor of Trk receptors, demonstrating remarkable in vitro potency against various TRK mutants with IC50 values ranging from 0.2 to 0.7 nM. This compound is invaluable for studying the role of Trk signaling in cancer and neurodevelopmental disorders. Its high specificity makes it a reliable tool for elucidating the biological effects of Trk inhibition in research applications.
Product Information
Catalog NumA35025
FormulaC21H21F3N6O2
Molecular Weight446.43
CAS Number2489327-43-5
SMILESFC1=CC=C(OCC(F)F)C([C@@H](C)NC2=NC3=C(C4=CN(CCO)N=C4)C=NN3C=C2)=C1
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