Fig. 1 · Structure
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Trk-IN-9
TRK Inhibitor
Trk-IN-9 is a potent TRK inhibitor that effectively suppresses the proliferation of Km-12 cell lines. This compound induces apoptosis in these cells in a concentration-dependent manner and inhibits TRK phosphorylation, thereby disrupting downstream signaling pathways. Trk-IN-9 holds promise for research related to NTRK-fusion cancers, making it a valuable tool for cancer biology investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2758623-12-8 |
| Applications | TRK Inhibitor |
| Formula | C23H24ClFN6O |
| Molecular Weight | 454.93 |
| SMILES | FC1=CC=CC(CNC2=NC(NC3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3)=NC=C2Cl)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.