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TrkA-IN-4

Catalog No.: A34979
TrkA Inhibitor
TrkA-IN-4 is a potent allosteric inhibitor of TrkA, functioning as a proagent of TrkA-IN-3 with an IC50 value of 22.4 nM. This compound demonstrates significant antinociceptive effects, making it an important tool for research in pain modulation and neurobiology. Its orally active formulation enhances its utility in pharmacological studies exploring the role of TrkA in various pain-related pathways.
TrkA-IN-4 3026111-74-7 TrkA Inhibitor
Grouped product items
Size Price Stock Qty
5mg
$55.00
In stock
10mg
$100.00
In stock
25mg
$210.00
In stock
50mg
$330.00
In stock
100mg
$480.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTrkA-IN-4 is a potent allosteric inhibitor of TrkA, functioning as a proagent of TrkA-IN-3 with an IC50 value of 22.4 nM. This compound demonstrates significant antinociceptive effects, making it an important tool for research in pain modulation and neurobiology. Its orally active formulation enhances its utility in pharmacological studies exploring the role of TrkA in various pain-related pathways.
Product Information
Catalog NumA34979
FormulaC27H21F3N4O5
Molecular Weight538.47
CAS Number3026111-74-7
SMILESCC(OCOC(C1=CN=C(C(NC(C2=CC=C(C(C3=NN(C=C3)C)=C2)C(F)(F)F)=O)=C1)C4=CC=CC=C4)=O)=O
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
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Protein Tyrosine Kinases > Trk Receptors