Fig. 1 · Structure
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Tropisetron-d5
Stable Isotope
Tropisetron-d5 is a deuterium-labeled variant of the antiemetic and anti-inflammatory agent Tropisetron, which functions primarily as a selective 5-HT3 receptor antagonist with a Ki value of 5.3 nM. Additionally, Tropisetron acts as a partial agonist at the α7 nicotinic acetylcholine receptor, exhibiting an EC50 of 1.3 μM. This compound also demonstrates antitumor and neuroprotective properties, making it valuable for research in neuropharmacology and cancer therapy. Analyses utilizing stable isotopes like Tropisetron-d5 can enhance the understanding of its biological activity and therapeutic potential.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1220284-86-5 |
| Applications | Stable Isotope |
| Formula | C17H15D5N2O2 |
| Molecular Weight | 289.38 |
| Synonyms | SDZ-ICS-930-d5 free base |
| SMILES | O=C(C1=C([2H])NC2=C1C([2H])=C([2H])C([2H])=C2[2H])O[C@H]3C[C@H]4CC[C@H](N4C)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.