Fig. 1 · Structure
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TRULI
Lat1/2 kinases Inhibitor
TRULI (Lats-IN-1) is a potent ATP-competitive inhibitor targeting Lats1 and Lats2 kinases. This compound has been shown to promote Yap-dependent proliferation in postmitotic mammalian tissues, making it a valuable tool for investigating cellular growth and development processes. TRULI can be utilized in research applications focused on mechanistic studies of Hippo signaling pathway regulation and related oncogenic processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1424635-83-5 |
| Applications | Lat1/2 kinases Inhibitor |
| Formula | C18H14N4OS |
| Molecular Weight | 334.39 |
| Synonyms | Lats-IN-1 |
| SMILES | O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.