Fig. 1 · Structure
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TRV-120027
AT1R Antagonist
TRV-120027 is an AT1R antagonist that selectively engages β-arrestin-1 while inhibiting G-protein signaling pathways. This compound is known to induce acute catecholamine secretion through the activation of the TRPC3 cation channel, facilitating the formation of a macromolecular complex involving AT1R, β-arrestin-1, TRPC3, and PLCγ at the plasma membrane. TRV-120027 effectively inhibits angiotensin II-mediated vasoconstriction and enhances contractility in cardiomyocytes, highlighting its potential application for treating acute decompensated heart failure (ADHF).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1234510-46-3 |
| Applications | AT1R Antagonist |
| Formula | C43H67N13O10 |
| Molecular Weight | 926.07 |
| Synonyms | TRV027 |
| SMILES | [H][C@](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC)C(C)C)([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.