Fig. 1 · Structure
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Tryptamine guanosine carbamate
HINT1 Inhibitor
Tryptamine guanosine carbamate (TpGc) is a selective inhibitor of the histidine triad nucleotide-binding protein 1 (HINT1), exhibiting a Ki value of 34 μM and a Kd of 3.65 μM. This compound significantly potentiates the antinociceptive effects of morphine while effectively mitigating the development of opioid tolerance. TpGc serves as a valuable tool in pain research and the development of strategies to enhance analgesic efficacy without the associated tolerance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1414808-96-0 |
| Applications | HINT1 Inhibitor |
| Formula | C21H23N7O6 |
| Molecular Weight | 469.45 |
| Synonyms | TpGc |
| SMILES | O[C@H]1[C@@H](O)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COC(NCCC4=CNC5=CC=CC=C45)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.