TSPO ligand-2 is a ligand of AUTAC1, specifically designed to target the MetAP2 enzyme. This compound features a p-fluorobenzylguanine (FBnG) moiety and a Fumagillol component, facilitating the selective degradation of MetAP2 within HeLa cells. It serves as a valuable tool for studying the regulation of protein homeostasis and the therapeutic potential of targeted protein degradation strategies in cellular models.
TSPO ligand-2 is a ligand of AUTAC1, specifically designed to target the MetAP2 enzyme. This compound features a p-fluorobenzylguanine (FBnG) moiety and a Fumagillol component, facilitating the selective degradation of MetAP2 within HeLa cells. It serves as a valuable tool for studying the regulation of protein homeostasis and the therapeutic potential of targeted protein degradation strategies in cellular models.
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