Fig. 1 · Structure
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TT-012
MITF Inhibitor
TT-012 is a selective inhibitor of the microphthalmia-associated transcription factor (MITF), functioning by disrupting MITF dimerization and its DNA-binding capacity. This compound effectively inhibits the transcriptional activity of MITF in B16F10 melanoma cells, leading to a reduction in the proliferation of high-MITF melanoma cells. Additionally, TT-012 demonstrates significant anti-tumor effects by inhibiting both tumor growth and metastasis in preclinical animal models while exhibiting manageable toxicity to liver and immune cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1164471-33-3 |
| Applications | MITF Inhibitor |
| Formula | C19H15N3O4 |
| Molecular Weight | 349.34 |
| SMILES | O=C(/C=C/C1=CC=CO1)NC2=CC=CC(NC(/C=C/C3=CC=CO3)=O)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.