Fig. 1 · Structure
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TTA-A2
T-type Voltage-Gated Ca2+ Channel Blocker
TTA-A2 is a selective antagonist of T-type voltage-gated calcium channels, specifically targeting Cav3.1 and Cav3.2. With IC50 values of 89 nM and 92 nM at -80 mV and -100 mV holding potentials, respectively, TTA-A2 exhibits strong inhibitory activity while minimizing pregnane X receptor activation. This compound is valuable for investigating a range of human neurological disorders, including sleep disorders and epilepsy, making it a useful tool for research in the field of neuroscience.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 953778-63-7 |
| Applications | T-type Voltage-Gated Ca2+ Channel Blocker |
| Formula | C20H21F3N2O2 |
| Molecular Weight | 378.39 |
| SMILES | O=C(N[C@@H](C1=NC=C(OCC(F)(F)F)C=C1)C)CC2=CC=C(C3CC3)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.