Fig. 1 · Structure
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TTFB
ZAC Antagonist
TTFB is a selective, non-competitive antagonist of the zinc-activated channel (ZAC). It effectively inhibits ZAC currents induced by Zn²⁺ and H⁺, exhibiting IC50 values of 3 μM and 8.5 μM, respectively, and demonstrates an IC50 of 4.7 μM against spontaneous channel activity. TTFB shows no significant activity on classical Cys-loop receptors, such as m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR, and hα1 GlyR. This compound is valuable for studying the physiological and pathological roles of ZAC in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 352560-76-0 |
| Applications | ZAC Antagonist |
| Formula | C14H15FN2OS |
| Molecular Weight | 278.35 |
| Synonyms | N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide |
| SMILES | O=C(NC1=NC(=CS1)C(C)(C)C)C=2C=CC=C(F)C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.