Fig. 1 · Structure
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Tucatinib hemiethanolate
HER2 Inhibitor
Tucatinib hemiethanolate is a selective inhibitor of the HER2 receptor, displaying potent activity with an IC50 of 8 nM. This orally bioavailable compound is primarily utilized in cancer research, particularly in studies focusing on HER2-positive tumors. Tucatinib's mechanism of action contributes to the understanding of targeted therapies in oncology, making it a valuable reagent for investigating therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1429755-56-5 |
| Applications | HER2 Inhibitor |
| Formula | C26H24N8O2.1/2C2H6O |
| Molecular Weight | 503.57 |
| Synonyms | Irbinitinib hemiethanolate; ARRY-380 hemiethanolate; ONT-380 hemiethanolate |
| SMILES | CC1=CC(NC2=C3C=C(NC4=NC(C)(C)CO4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5.CCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.