Fig. 1 · Structure
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TX-1918
eEF2 Kinase Inhibitor
TX-1918 is a selective inhibitor of eukaryotic elongation factor 2 kinase (eEF2-K) and also targets Src kinase, demonstrating IC50 values of 0.44 µM and 4.4 µM, respectively. This compound exhibits cytotoxic effects on HepG2 and HCT116 cell lines, with IC50 values of 2.07 µM and 230 µM. Additionally, TX-1918 inhibits the C-terminal domain of HIV-1 capsid protein (CA CTD) with an IC50 of 3.81 µM and displays antiviral activity by reducing viral replication (IC50 = 15.16 µM). Its biological activity makes it a valuable tool for research in cancer and virology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 503473-32-3 |
| Applications | eEF2 Kinase Inhibitor |
| Formula | C14H12O3 |
| Molecular Weight | 228.24 |
| SMILES | O=C1/C(C(C=C1)=O)=C\C2=CC(C)=C(O)C(C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.