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Tyk2-IN-16

TYK2 Inhibitor

Tyk2-IN-16 is a selective and potent inhibitor of TYK2, demonstrating an IC50 of less than 10 nM for the TYK2-JH2 domain. It efficiently inhibits the phosphorylation of STAT4 (pSTAT4) with an IC50 of less than 10 nM in NK92 cells. This compound is primarily utilized in research related to autoimmune disorders and inflammatory conditions, providing valuable insights into TYK2-mediated signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3010874-30-0
Applications	TYK2 Inhibitor
Formula	C₂₀H₂₀F₂N₈O
Molecular Weight	426.42
SMILES	N#CC1(CN(CC1)C2=NN(C3=C2C=NC(NC(C)=O)=C3)C4=NC=CC(C(F)(C)F)=N4)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.