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TYK2 ligand 2

TYK2 Ligand

TYK2 Ligand 2 is a ligand targeting TYK2 and is associated with the selective CRBN-recruited TYK2 PROTAC degrader, TYD-68, exhibiting a DC50 value of 0.42 nM. This compound is valuable for investigating the biological mechanisms underlying psoriasis and other TYK2-related disorders. Its precise activity supports research into targeted degradation pathways, facilitating a deeper understanding of therapeutic strategies for autoimmune diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2924460-80-8
Applications	TYK2 Ligand
Formula	C₂₄H₂₀FN₇O₄
Molecular Weight	489.46
SMILES	COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(O)=O)=NC=C3C(NC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.