Fig. 1 · Structure
Documents & Downloads
(-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488)
KOR Agonist
(-)-U-50488 hydrochloride is a selective agonist of the kappa-opioid receptor (KOR), exhibiting a binding affinity (Kd) of 2.2 nM, significantly higher than its affinity for the μ-opioid receptor (MOR) at 430 nM. This compound serves as a more active enantiomer compared to its (+) counterpart and the racemic mixture. In research applications, (-)-U-50488 hydrochloride demonstrates potent and sustained anti-HIV activity in infected blood monocyte-derived macrophages (MDM), making it a valuable tool for studying kappa-opioid receptor functions and their therapeutic potential in HIV-related research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 114528-79-9 |
| Applications | KOR Agonist |
| Formula | C19H27Cl3N2O |
| Molecular Weight | 405.79 |
| Synonyms | (-)-Trans-(1S,2S)-U-50488 hydrochloride; (-)-Trans-(1S,2S)-U-50488 |
| SMILES | O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.