(-)-U-50488 hydrochloride is a selective agonist of the kappa-opioid receptor (KOR), exhibiting a binding affinity (Kd) of 2.2 nM, significantly higher than its affinity for the μ-opioid receptor (MOR) at 430 nM. This compound serves as a more active enantiomer compared to its (+) counterpart and the racemic mixture. In research applications, (-)-U-50488 hydrochloride demonstrates potent and sustained anti-HIV activity in infected blood monocyte-derived macrophages (MDM), making it a valuable tool for studying kappa-opioid receptor functions and their therapeutic potential in HIV-related research.
(-)-U-50488 hydrochloride is a selective agonist of the kappa-opioid receptor (KOR), exhibiting a binding affinity (Kd) of 2.2 nM, significantly higher than its affinity for the μ-opioid receptor (MOR) at 430 nM. This compound serves as a more active enantiomer compared to its (+) counterpart and the racemic mixture. In research applications, (-)-U-50488 hydrochloride demonstrates potent and sustained anti-HIV activity in infected blood monocyte-derived macrophages (MDM), making it a valuable tool for studying kappa-opioid receptor functions and their therapeutic potential in HIV-related research.
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