Fig. 1 · Structure

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UB-221

Anti-IgE Antibody

UB-221 is a humanized IgG1 monoclonal antibody that specifically targets IgE. It effectively reduces IgE synthesis by stabilizing membrane-bound CD23 on B lymphocytes and inhibits FcεRI-mediated basophil activation and degranulation. This compound has demonstrated the ability to lower IgE levels in cynomolgus macaques and human IgE-transgenic mice. UB-221 is suitable for research applications related to asthma and chronic spontaneous urticaria (CSU).

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Specifications

Manufacturer Adooq Bioscience
CAS Number 2755114-30-6
Applications Anti-IgE Antibody
Formula Please refer to the lot-specific COA for specific buffer information.

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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