Fig. 1 · Structure
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Ubiquitination-IN-1
Ubiquitination Inhibitor
Ubiquitination-IN-1 is a potent inhibitor of ubiquitination and the Cksl-Skp2 protein-protein interaction, with an IC50 of 0.17 μM. This compound effectively increases the levels of the cyclin-dependent kinase inhibitor p27. Ubiquitination-IN-1 offers potential in therapeutic applications aimed at preventing the degradation of tumor suppressors, making it a valuable tool in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1819330-15-8 |
| Applications | Ubiquitination Inhibitor |
| Formula | C21H14F3N3O2S |
| Molecular Weight | 429.41 |
| SMILES | O=S(C1=CC=CC(C(F)(F)F)=C1)(NC2=C3N=CC=CC3=C(C4=CC=CN=C4)C=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.