UBP 1112 is a selective antagonist of group III metabotropic glutamate receptors (mGluRs), demonstrating a dissociation constant (Kd) of 5.1 μM. This compound exhibits a 96-fold preference for group III mGluRs over group II receptors, with a Kd value of 488 μM for the latter. UBP 1112 does not display significant activity at group I mGluRs or ionotropic glutamate receptors (iGluRs). This specificity positions UBP 1112 as a valuable tool for studying the physiological and pathological roles of group III mGluRs in various neurological research applications.
UBP 1112 is a selective antagonist of group III metabotropic glutamate receptors (mGluRs), demonstrating a dissociation constant (Kd) of 5.1 μM. This compound exhibits a 96-fold preference for group III mGluRs over group II receptors, with a Kd value of 488 μM for the latter. UBP 1112 does not display significant activity at group I mGluRs or ionotropic glutamate receptors (iGluRs). This specificity positions UBP 1112 as a valuable tool for studying the physiological and pathological roles of group III mGluRs in various neurological research applications.
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