UC-773587

Catalog No.: A65863
SOS1 Inhibitor
UC-773587 is a selective inhibitor of SOS1 catalytic activity. By specifically binding to the catalytic site of SOS1, it inhibits nucleotide exchange with an IC50 of 4.5 μM, while demonstrating minimal interaction with HRas and ITSN. This compound is valuable for research into signaling pathways and has potential applications in the study of prostate cancer.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionUC-773587 is a selective inhibitor of SOS1 catalytic activity. By specifically binding to the catalytic site of SOS1, it inhibits nucleotide exchange with an IC50 of 4.5 μM, while demonstrating minimal interaction with HRas and ITSN. This compound is valuable for research into signaling pathways and has potential applications in the study of prostate cancer.
Product Information
Catalog NumA65863
FormulaC28H15O5-
Molecular Weight431.42
CAS Number116679-70-0
SMILESOC(C=CC1=C2O3)=CC1=CC=C2C(C4=CC=CC=C4C([O-])=O)=C5C3=C6C=CC(C=C6C=C5)=O
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