Fig. 1 · Structure
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UCK2 Inhibitor-3
UCK2 Inhibitor
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a key enzyme involved in the pyrimidine salvage pathway, exhibiting an IC50 of 16.6 μM. By targeting UCK2, this compound disrupts nucleotide metabolism, particularly in rapidly dividing or infected cells, thereby affecting cellular proliferation. Additionally, UCK2 Inhibitor-3 demonstrates inhibitory activity against DNA polymerases eta and kappa, with IC50 values of 56 μM and 16 μM, respectively. This makes it a valuable tool for studying nucleotide biosynthesis and its implications in cancer and viral infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2376687-49-7 |
| Applications | UCK2 Inhibitor |
| Formula | C19H13BrFN5O2S |
| Molecular Weight | 474.31 |
| SMILES | O=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.