Fig. 1 · Structure
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UCL 1684 dibromide
SK Channel Blocker
UCL 1684 dibromide is a potent, non-peptidic blocker of small conductance calcium-activated potassium (SK) channels, exhibiting nanomolar potency. This compound demonstrates significant atrial-selective inhibition of sodium current (INa), effectively preventing the onset of atrial fibrillation. In addition, UCL 1684 dibromide induces atrial-selective prolongation of the effective refractory period (ERP) by promoting postrepolarization refractoriness, making it a valuable tool for researching cardiac electrophysiology and arrhythmogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 199934-16-2 |
| Applications | SK Channel Blocker |
| Formula | C34H30Br2N4 |
| Molecular Weight | 654.44 |
| SMILES | C12=[N+](CC3=CC(C[N+]4=CC=C(NCC5=CC=C(C=C5)CN6)C7=CC=CC=C47)=CC=C3)C=CC6=C1C=CC=C2.[Br-].[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.