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UCM-13369

NPM1 Inhibitor

UCM-13369 is an NPM1 inhibitor that specifically targets the C-terminal DNA-binding domain of the mutant NPM1 C+ protein. This compound effectively downregulates signaling pathways associated with NPM1 C+ mutations. UCM-13369 has demonstrated the ability to induce apoptosis in acute myeloid leukemia (AML) cell lines and primary patient cells, making it a valuable tool for research focused on the underlying mechanisms of AML.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2921944-77-4
Applications	NPM1 Inhibitor
Formula	C₂₅H₃₁N₃O
Molecular Weight	389.53
SMILES	N[C@@H]([C@@H]1CCNCC2CC2)[C@@H](C3=CC=C(OC)C=C3)CC4=C1C5=C(N4)C=CC=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.