Fig. 1 · Structure
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UM4118
Copper Ionophore
UM4118 is a copper ionophore that facilitates the induction of cuproptosis, a novel mitochondrial-dependent mode of cell death. This compound demonstrates significant efficacy in targeting acute myeloid leukemia (AML) cells with SF3B1 mutations, making it a valuable tool for research into AML pathogenesis and potential therapeutic strategies. Its unique mechanism of action positions UM4118 as a promising candidate for investigating treatments in hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 324530-92-9 |
| Applications | Copper Ionophore |
| Formula | C15H11N3O |
| Molecular Weight | 249.27 |
| SMILES | O=C(C1=NC=CC=C1)NC2=CC=CC3=CC=CN=C32 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.