UNC0379

Catalog No.: A14320

SETD8 HMTase inhibitor

UNC0379 Chemical Structure

CAS NO. 1620401-82-2

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$135.00
25 mg
$280.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies.
Targets
SETD8
7.9 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.2 mL 120.98 mL 241.97 mL
0.5 mM 4.84 mL 24.2 mL 48.39 mL
1 mM 2.42 mL 12.1 mL 24.2 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

*The above data is based on the productmolecular weight 413.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14320
Actions Inhibitor
M. Wt 413.28
Formula C23H35N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1620401-82-2
Synonyms UNC-0379, UNC 0379
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC

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