Fig. 1 · Structure
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UNC4203
MERTK Inhibitor
UNC4203 is a highly selective MERTK inhibitor that exhibits potent inhibitory activity, with an IC50 of 1.2 nM against MERTK and has significantly lower inhibition against related kinases, including IC50s of 140 nM for AXL, 42 nM for TYRO3, and 90 nM for FLT3. Due to its oral bioavailability and selectivity, UNC4203 is a valuable tool for investigating the role of MERTK in various biological processes. Its potential applications include cancer research and therapeutic development targeting MERTK-related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1818234-19-3 |
| Applications | MERTK Inhibitor |
| Formula | C30H44N6O |
| Molecular Weight | 504.71 |
| SMILES | O[C@@H]1CC[C@H](CC1)N2C=C(C3=CN=C(N=C32)N[C@@H](C)CCC)C4=CC=C(C=C4)CN5CCN(CCC5)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.