UniPR129 is a potent, orally active antagonist of Eph/ephrin interactions. It effectively inhibits the EphA2-ephrin-A1 interaction with an IC50 of 945 nM and a Ki of 370 nM. This compound has demonstrated the ability to inhibit angiogenesis and exhibits both antitumor and neuroprotective properties. UniPR129 is suitable for research applications in cancer and neurological disorders, including colorectal cancer and optic neuropathy.
UniPR129 is a potent, orally active antagonist of Eph/ephrin interactions. It effectively inhibits the EphA2-ephrin-A1 interaction with an IC50 of 945 nM and a Ki of 370 nM. This compound has demonstrated the ability to inhibit angiogenesis and exhibits both antitumor and neuroprotective properties. UniPR129 is suitable for research applications in cancer and neurological disorders, including colorectal cancer and optic neuropathy.
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