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UniPR500

Catalog No.: A84705
EphA2 Receptor Antagonist
UniPR500 is a competitive antagonist of the EphA2 receptor, exhibiting a Ki value of 0.78 μM. This compound effectively inhibits the binding of biotinylated ephrin-A1 to EphA2 in a dose-dependent manner, with an IC50 of 1.1 μM. UniPR500 is valuable for research applications focusing on cellular signaling pathways and the role of EphA2 in various diseases.
UniPR500 2085767-98-0 EphA2 Receptor Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionUniPR500 is a competitive antagonist of the EphA2 receptor, exhibiting a Ki value of 0.78 μM. This compound effectively inhibits the binding of biotinylated ephrin-A1 to EphA2 in a dose-dependent manner, with an IC50 of 1.1 μM. UniPR500 is valuable for research applications focusing on cellular signaling pathways and the role of EphA2 in various diseases.
Product Information
Catalog NumA84705
FormulaC36H51N3O4
Molecular Weight589.81
CAS Number2085767-98-0
SMILESC[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N[C@H](CC(O)=O)CC3=CNC4=CC=CC=C34)=O)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6([C@](C/C(CC6)=N/O)([H])CC5)C
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Protein Tyrosine Kinases > Ephrin Receptor