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Upamostat hydrogen sulfate

Serine Protease Inhibitor

Upamostat hydrogen sulfate is an orally active serine protease inhibitor that targets the urokinase-type plasminogen activator (uPA) system. By inhibiting this pathway, it effectively blocks plasminogen activation, which is crucial in suppressing tumor cell invasion, migration, and metastasis. This compound is relevant for research into metastatic breast cancer and locally advanced pancreatic cancer, providing valuable insights into therapeutic strategies against these malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	798560-68-6
Applications	Serine Protease Inhibitor
Formula	C₆₄H₉₆N₁₀O₁₆S₃
Molecular Weight	1357.70
Synonyms	WX-671 hydrogen sulfate
SMILES	O=C(N1CCN(C([C@@H](NS(=O)(C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)=O)CC3=CC=CC(C(NO)=N)=C3)=O)CC1)OCC.O=C(N4CCN(C([C@@H](NS(=O)(C5=C(C(C)C)C=C(C(C)C)C=C5C(C)C)=O)CC6=CC=CC(C(NO)=N)=C6)=O)CC4)OCC.O=S(O)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.