Fig. 1 · Structure
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UPF-523
mGlu1a antagonist
UPF-523 is a selective antagonist of the group I metabotropic glutamate receptor mGlu1a, exhibiting a potency with an IC50 of 214 µM. This compound does not influence group II (mGlu2), group III (mGlu4), or ionotropic glutamate receptors. UPF-523 serves as a valuable tool in research related to acute arthritis, facilitating the investigation of therapeutic strategies targeting mGlu1a receptor pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 168560-79-0 |
| Applications | mGlu1a antagonist |
| Formula | C11H11NO4 |
| Molecular Weight | 221.21 |
| Synonyms | AIDA |
| SMILES | O=C(C1(N)CCC2=C1C=CC(C(O)=O)=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.