Fig. 1 · Structure
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UR-PI376
H4R Agonist
UR-PI376 is a highly selective agonist of the histamine H4 receptor (H4R), exhibiting a pEC50 value of 7.47. This compound demonstrates minimal activity at the human H1 and H2 receptors, alongside moderate inverse agonistic effects at the H3 receptor. UR-PI376 is valuable for research into histamine-related pathways and conditions, making it a useful tool in the study of allergic responses, inflammation, and immunological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1192559-94-6 |
| Applications | H4R Agonist |
| Formula | C17H22N6S |
| Molecular Weight | 342.46 |
| SMILES | N#CN/C(NCCSC1=CC=CC=C1)=N\CCCCC2=CN=CN2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.