Fig. 1 · Structure
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UR778Br
IQGAP1 Inhibitor
UR778Br is a selective inhibitor targeting the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. It exhibits prominent anti-proliferative effects against human acute myeloid leukemia (AML) by arresting the cell cycle at the G2/M phase and inducing apoptosis. Additionally, UR778Br effectively inhibits the colony formation of both primary and AML cells while demonstrating minimal effects on normal bone marrow cells, making it a valuable tool for cancer research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 866127-80-2 |
| Applications | IQGAP1 Inhibitor |
| Formula | C20H20BrNO4 |
| Molecular Weight | 418.28 |
| SMILES | CCCCN1C(C(CC(C2=CC=CC=C2O)=O)(C3=C1C=CC(Br)=C3)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.