Fig. 1 · Structure
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URAT1 inhibitor 4
URAT1 Inhibitor
URAT1 Inhibitor 4 is a potent and orally active inhibitor of the urate transporter 1 (URAT1), exhibiting an IC50 of 7.56 μM. This compound demonstrates enhanced urate-lowering efficacy in vivo compared to its precursor, Lesinurad. It is valuable for research applications aimed at understanding gout treatment mechanisms and the modulation of uric acid levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2700292-02-8 |
| Applications | URAT1 Inhibitor |
| Formula | C27H20BrN3O4S3 |
| Molecular Weight | 626.56 |
| SMILES | O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.