Fig. 1 · Structure
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Urotensin I
CRF Receptor Agonist
Urotensin I is a CRF receptor agonist with high affinity for human CRF1, human CRF2, and rat CRF2α receptors, demonstrating pEC50 values of 11.46, 9.36, and 9.85, respectively. It exhibits inhibition constants (Kis) of 0.4 nM for hCRF1, 1.8 nM for rCRF2α, and 5.7 nM for mCRF2β receptors in CHO cells. This neuropeptide is valuable for research into stress response mechanisms and neuroendocrine regulation, making it a useful tool for studying the CRF signaling pathway and its implications in various physiological and pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 83930-33-0 |
| Applications | CRF Receptor Agonist |
| Formula | C210H340N62O67S2 |
| Molecular Weight | 4869.46 |
| Synonyms | Catostomus urotensin I |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.