UZH1 is a METTL3 inhibitor that comprises a racemic mixture of UZH1a and UZH1b. UZH1a is a highly selective inhibitor, displaying an IC50 of 280 nM, while UZH1b shows minimal activity with an IC50 of 28 µM. UZH1 serves as an effective tool for epitranscriptomic modulation of cellular processes and demonstrates antitumor activity. Additionally, UZH1 can be utilized as a chemical probe for in-depth investigations of METTL3's role in various biological contexts.
UZH1 is a METTL3 inhibitor that comprises a racemic mixture of UZH1a and UZH1b. UZH1a is a highly selective inhibitor, displaying an IC50 of 280 nM, while UZH1b shows minimal activity with an IC50 of 28 µM. UZH1 serves as an effective tool for epitranscriptomic modulation of cellular processes and demonstrates antitumor activity. Additionally, UZH1 can be utilized as a chemical probe for in-depth investigations of METTL3's role in various biological contexts.
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