V-11-0711 is a potent and selective inhibitor of Chk-α, exhibiting an IC50 value of 20 nM. This compound effectively reduces phosphocholine (PCho) levels and induces reversible growth arrest in various cancer cell lines. At elevated concentrations, V-11-0711 can promote apoptosis. It is particularly useful for research related to cervical cancer and triple-negative breast cancer, facilitating the exploration of therapeutic strategies targeting Chk-α pathways.
V-11-0711 is a potent and selective inhibitor of Chk-α, exhibiting an IC50 value of 20 nM. This compound effectively reduces phosphocholine (PCho) levels and induces reversible growth arrest in various cancer cell lines. At elevated concentrations, V-11-0711 can promote apoptosis. It is particularly useful for research related to cervical cancer and triple-negative breast cancer, facilitating the exploration of therapeutic strategies targeting Chk-α pathways.
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