Fig. 1 · Structure
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VA-K-14 hydrochloride
TSHR Antagonist
VA-K-14 hydrochloride is a selective antagonist of the thyroid-stimulating hormone receptor (TSHR), exhibiting an IC50 of 12.3 μM. This compound is valuable for research applications aimed at understanding TSHR signaling pathways and its implications in thyroid-related disorders. By inhibiting TSHR activity, VA-K-14 hydrochloride aids in the exploration of potential therapeutic strategies targeting thyroid hormone regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1171341-19-7 |
| Applications | TSHR Antagonist |
| Formula | C18H16ClN3S |
| Molecular Weight | 341.86 |
| SMILES | CNC1=NC(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=CS1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.