Fig. 1 · Structure
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Vacquinol-1 dihydrochloride
MKK4 Activator
Vacquinol-1 dihydrochloride is a selective MKK4 activator that stimulates MAPK signaling pathways. This compound has been shown to induce cytotoxicity in human glioblastoma cells, inhibit tumor growth, and enhance survival in mice models of glioblastoma multiforme. Additionally, Vacquinol-1 dihydrochloride promotes apoptosis in hepatocellular carcinoma cells, making it a valuable tool for research into cancer therapies and signaling modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2309312-85-2 |
| Applications | MKK4 Activator |
| Formula | C21H23Cl3N2O |
| Molecular Weight | 425.78 |
| Synonyms | NSC13316 dihydrochloride |
| SMILES | OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.