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Val-Cit-Exatecan

ADC Intermediate

Val-Cit-Exatecan is a peptide-linked anti-tumor agent designed for the synthesis of antibody-drug conjugates (ADCs) targeting various cancers. This compound combines the DNA Topoisomerase I inhibitor Exatecan with a cathepsin-cleavable linker composed of valine and citrulline. Val-Cit-Exatecan is primarily utilized in research focused on colorectal, gastric, breast, non-small cell lung, ovarian, head and neck, pancreatic, cervical cancers, and melanoma, facilitating targeted therapeutic approaches in oncology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2952679-21-7
Applications	ADC Intermediate
Formula	C₃₈H₄₇FN₈O₉
Molecular Weight	778.83
SMILES	CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NCOCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.