Fig. 1 · Structure
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Val-Cit-PAB-Exatecan TFA
Drug-Linker Conjugate
Val-Cit-PAB-Exatecan TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, targeting DNA topoisomerase I. This compound incorporates Exatecan, a potent cytotoxic agent, connected via a cathepsin-cleavable linker. Val-Cit-PAB-Exatecan TFA is used in research focused on ADC development, enabling selective delivery of chemotherapeutics to tumor cells through the targeted release mechanism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2928571-44-0 |
| Applications | Drug-Linker Conjugate |
| Formula | C45H50F4N8O11 |
| Molecular Weight | 954.92 |
| Synonyms | Val-Cit-PAB-DX8951 TFA |
| SMILES | CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O.O=C(O)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.